Osteosarcoma Models: From Cell Lines to Zebrafish
نویسندگان
چکیده
منابع مشابه
Osteosarcoma Models: From Cell Lines to Zebrafish
High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents. The early age of onset might suggest genetic predisposition; however, the vast majority of the tumors are sporadic. Early onset, most often lack of a predisposing condition or lesion, only infrequent (<2%) prevalence of inheritance, extensive genomic instability, and a wide histological heterogeneity are just fe...
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Telomere studies in carcinomas have been extensively reported for prognostic utility and effective methods for targeting telomerase therapy has been described, but efficacy of telomerase inhibitor remained unknown in sarcoma cells. In this study, we investigated the effects of telomerase inhibitor cationic porphyrin TMPyP4 on telomerase activity, telomere length, cell growth, and apoptosis in o...
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ژورنال
عنوان ژورنال: Sarcoma
سال: 2012
ISSN: 1357-714X,1369-1643
DOI: 10.1155/2012/417271